COMPARISON OF ISOCONAZOLE NITRATE VERSUS NYSTATIN FOR TREATMENT OF OTOMYCOSIS

  • Muhammad Ahmed Khan Combined Military Hospital Mardan/National University of Medical Sciences (NUMS) Pakistan
  • Bushra Anwar Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Sumera Akram Mardan Medical Complex, Mardan Pakistan
  • Attique Ahmed Combined Military Hospital Lahore/National University of Medical Sciences (NUMS) Pakistan
  • Sunarays Akhtar Pakistan Air Force Hospital, Jacobabad Pakistan
  • Maqbool Raza Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Keywords: Otomycosis, Isoconazole, Nystatin

Abstract

Objective: To compare isoconazole nitrate versus nystatin for treatment of otomycosis.

Study Design: Quasi experimental study.

Place and Duration of Study: Combined Military Hospital Bahawalpur and Combined Military Hospital Mardan, from Jan to Dec 2018.

Methodology: Total 204 cases fulfilling the inclusion criteria were selected from outpatient department of Combined Military Hospital Bahawalpur and Mardan. They were divided into 2 groups of 102 each using random number tables. Group A cases were given Isocona-zole nitrate for application in external auditory meatus and group B cases were given Nystatin. All the cases were examined two weeks later and outcome was compared in terms of clinical improvement and symptoms resolution.

Results: Out of 204, 125 patients were females and rest 79 were males. Age range was from 12-87 years with mean age 31 ± 2.4. Both groups were identical in terms of gender. In group A patients, 74 (72.5%) showed marked improvement after two week, 15 (14.7%) showed moderate improvement and 13 (12.7%) showed minor improvement. However, in group B, 55 (53.9%) showed marked improvement after two week, 23 (22.5%) showed moderate improvement and 24 (23.5%) showed minor improvement. Group A treatment was found significantly better than group B treatment (p=0.021).

Conclusion: Isoconazole nitrate ointment was found significantly more effective for treating otomycosis than nystatin.

Downloads

Download data is not yet available.
Published
2021-12-28
How to Cite
Khan, M., Anwar, B., Akram, S., Ahmed, A., Akhtar, S., & Raza, M. (2021). COMPARISON OF ISOCONAZOLE NITRATE VERSUS NYSTATIN FOR TREATMENT OF OTOMYCOSIS. Pakistan Armed Forces Medical Journal, 71(Suppl-3), S581-84. https://doi.org/10.51253/pafmj.v1i1.7949
Section
Original Articles