DISAPPEARANCE OF ANTIBODIES IN COVID-19 MYTHS ORREALITY

  • Maqbool Raza Combined Military Hospital Multan/National University of Medical Sciences (NUMS) Pakistan
  • Muhammed Ali Raza Islamabad Medical and Dental College, Islamabad Pakistan
  • De Emmal Asjad Cheema Pakistan Medical Commission, Islamabad Pakistan
  • Maham Asjad Cheema Islamabad Medical and Dental College, Islamabad Pakistan
  • Atif Rafique Combined Military Hospital Multan/National University of Medical Sciences (NUMS) Pakistan
  • Sarim Waleed Khan Shifa College of Medicine, Islamabad Pakistan
Keywords: Antibodies, COVID-19, Disappearance, Myths, Reality

Abstract

Objective: To explore the disappearance of neutralizing antibodies from patients, their myths, and facts.

Study Design: Cross-sectional study.

Place and Duration of Study: Combined Military Hospital Multan Pakistan, from Jul 2021 to Aug 2021.

Methodology: A total of 100 blood samples were collected from 100 COVID-19 patients. These 100 patients were followed up for a period of 3 months. Antibodies were determined with the modified neutralization assay method and enzyme-linked immuno-sorbent assay (ELISA).

Results: The antibody level by NA and ELISA peaked on days 30-35 then decreased slightly. In multivariate analysis, patients aged 25-35, 36-56, and 57-84 years had a higher neutralizing antibody level than those aged 10-21 years. The patient with the worst clinical manifestation had a higher neutralizing antibody titer. In serum samples, IgG was undetectable at 18.3% and 11% and the geographical mean reciprocal titers dropped from 244 at 3-month period and neutralizing antibodies, the geographical mean reciprocal titers dropped from 874 at 3 months.

Conclusion: All COVID-19 patients were seropositive and significantly neutralizing antibody response. Neutralizing antibody levels depend on the time after the onset of symptoms, age, and severity of the disease.

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Published
2021-12-28
How to Cite
Raza, M., Raza, M., Cheema, D. E., Cheema, M., Rafique, A., & Khan, S. (2021). DISAPPEARANCE OF ANTIBODIES IN COVID-19 MYTHS ORREALITY. Pakistan Armed Forces Medical Journal, 71(Suppl-3), S530-33. https://doi.org/10.51253/pafmj.v1i1.7940
Section
Original Articles

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