INTER-OBSERVER VARIABILITY IN GLEASON SCORING SYSTEM F0R HISTOLOGICAL GRADING OF ADENOCARCINOMA PROSTATE

  • Farah Ahsan AFIP
  • Ahmed Ahson Khan
  • Muhammad Asif
  • Maria Aslam
  • Saba Hamayun
  • Hafeez Ud Din
Keywords: Prostate cancer, Gleason scoring, Inter-observer variability

Abstract

ABSTRACT

Objective: To evaluate the reproducibility of the Gleason scoring system and to compare its inter-observer variability for histological grading of prostatic adenocarcinoma.

Study Design: Prospective double-blind study.

Place and Duration of Study: Histopathology department of Armed Forces Institute of Pathology (Jan-Jul 2020).

Methodology: A total of 128 pathology slides of prostate biopsies from patients with prostate cancer were re-evaluated. The International Society of Urological Pathology 2005 modified Gleason grading system with Epstein’s modification was used. Two pathologists, blinded to each other and to the initial pathology report, performed the pathological evaluation. To determine inter-observer concordance, the kappa coefficient test was used.

Results: Concordance rates between the two observers for Gleason pattern sums were 67% (Ꝁ=0.556, 95% CI 0.40-0.59), respectively. Best concordance was at Gleason sum 7 (n=30/128).

Conclusion: The agreement between observers on the Gleason sum was moderate. It can be greatly reduced if better trained uropathologists employ the Gleason scoring system resulting in less variability and more conformity.

 

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Author Biographies

Ahmed Ahson Khan

Consultant Histopathologist

Armed Forces Institute of Pathology (AFIP), Rawalpindi

Muhammad Asif

Consultant Histopathologist

Armed Forces Institute of Pathology (AFIP), Rawapindi

Maria Aslam

Consultant Histopathologist 

Army Medical College, Rawalpindi

Saba Hamayun

Resident Histopathology

AFIP, Rawalpindi

Hafeez Ud Din

Consultant Histopathologist

Commandant AFIP, Rwp

Published
2022-03-16
How to Cite
Ahsan, F., Khan, A., Asif, M., Aslam, M., Hamayun, S., & Din, H. (2022). INTER-OBSERVER VARIABILITY IN GLEASON SCORING SYSTEM F0R HISTOLOGICAL GRADING OF ADENOCARCINOMA PROSTATE. PAFMJ, 72(1), 327-30. https://doi.org/10.51253/pafmj.v72i1.7776
Section
Original Articles