Comparison of Dexmedetomidine and Fentanyl for Blunting Hemodynamic Response to Intubation

  • Abid Khan Combined Military Hospital Peshawar/National University of Medical Sciences (NUMS) Pakistan
  • Shizan Hamid Feroz Combined Military Hospital Peshawar/National University of Medical Sciences (NUMS) Pakistan
  • Sana Iqbal Armed Forces Post Graduate Medical Institute/National University of Medical Sciences (NUMS) Rawalpindi, Pakistan
  • Zafarullah Khan Combined Military Hospital Sialkot/National University of Medical Sciences (NUMS) Pakistan
  • Talha Yaseen Combined Military Hospital Kohat/National University of Medical Sciences (NUMS) Pakistan
  • Shahum Khan Combined Military Hospital Risalpur/National University of Medical Sciences (NUMS) Pakistan
Keywords: Dexmedetomidine, Fentanyl, Heart rate, Intubation, Mean arterial pressure

Abstract

Objective: To compare the effects of Dexmedetomidine and Fentanyl on the blunting of the hemodynamic response to intubation.

Study Design: Comparative cross-sectional study.

Place and Duration of Study: Combined Military Hospital Peshawar Pakistan, from Jan to Aug 2021.

Methodology: This study was conducted on 908 patients who were ASA grades I and II and underwent general anaesthesia for any surgical procedure. Group-A received Dexmedetomidine, while Group-B received Fentanyl and routine preanaesthetic medications. Hemodynamic responses in both groups were recorded and compared in heart rate and mean arterial pressure at baseline, 2, 5, and 10 minutes after the intubation.

Results: Out of 908 patients equally divided into two groups, 579 (63.7%) were males, while 329 (36.3%) were females. The mean age of patients included in our study was 33.445 6.363 years. A significant increase in heart rate was found at 2, 5 and 10 minutes in the group who took Fentanyl compared to the group who took Dexmedetomidine (p-value 0.001).  ignificant increases in mean arterial pressure were found at 2 and 5 minutes (p-value 0.019 and 0.007, respectively) in the Fentanylgroup, while no significant difference was found at 10 minutes in either group (p-value 0.914).

Conclusion: In this study, Dexmedetomidine was found to be a better agent in providing hemodynamic stability during and after the process of intubation compared to Fentanyl.

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Published
2022-04-29
How to Cite
Khan, A., Feroz, S., Iqbal, S., Khan, Z., Yaseen, T., & Khan, S. (2022). Comparison of Dexmedetomidine and Fentanyl for Blunting Hemodynamic Response to Intubation. Pakistan Armed Forces Medical Journal (PAFMJ), 72(2), 394-97. https://doi.org/10.51253/pafmj.v72i2.7517
Section
Original Articles