Impact of Aqueous Neem Leave Extract on Erythromycin Induced Hepatotoxicity

  • Nausheen Jamshed Fauji Foundation Hospital Islamabad Pakistan
  • Iffat Raza Karachi Institute of Medical Sciences, Karachi/National University of Medical Sciences (NUMS) Pakistan
  • Aqiba Rasheed Islam Medical and Dental College, Sialkot Pakistan
  • Naureen Jamshed Queen Mary University of London, London, England
  • Lubna Akhtar Fauji Foundation Hospital Islamabad Pakistan
  • Nadia Rashid Fauji Foundation Hospital Islamabad Pakistan
Keywords: Azadirachtica indica, Erythromycin, Hepatotoxicity

Abstract

Objective: To examine the protective effect of aqueous neem leaves extract against damage induced by erythromycin on liver enzyme alkaline phosphatase.

Study Design: Laboratory-based experimental study.

Place and Duration of Study: Anatomy Department, Baqai Medical University, Karachi Pakistan, from Mar to Jun 2018.

Methodology: Eighty male albino wistar rats were taken and were divided randomly into 4 groups. Group-A served as a control group with no drug given. Group-B animals received the drug erythromycin 100 mg/kg body weight orally through gastric lavage. Group-C animals received erythromycin 100 mg/kg body weight and neem leaves extract in a dose of 500 mg/kg body weight orally through gastric lavage. Group-D received only neem extract at the dose of 500 mg/kg body weight orally. After 14 days, blood samples were collected via cardiac puncture and sent to laboratory for the investigation of alkaline phosphatase enzyme.

Results: The alkaline phosphatase enzyme levels of group-B (Erythromycin treated group) were found to be 176.98 ± 10.53 IU/L. When treated with aqueous neem leaves extract the alkaline phosphatase levels decreased to 150.10 ± 2.28 IU/L seen in group-C. The comparisons of group-B and group-C showed statistically significant (p<0.01), showing protective effect of aqueous neem leaves on hepatocytes.

Conclusion: Aqueous neem extract showed protective effect on erythromycin induced hepatic damage.

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Published
2022-03-01
How to Cite
Jamshed, N., Raza, I., Rasheed, A., Jamshed, N., Akhtar, L., & Rashid, N. (2022). Impact of Aqueous Neem Leave Extract on Erythromycin Induced Hepatotoxicity. PAFMJ, 72(1), 235-39. https://doi.org/10.51253/pafmj.v72i1.6756
Section
Original Articles