FREQUENCY OF HYPERURICEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE AND ITS ASSOCIATION WITH DISEASE SEVERITY, AGE, GENDER, DIABETES MELLITUS, AND HYPERTENSION

  • Syed Ahmad Raza 136 medical Battalion Jumber /National University of Medical Sciences (NUMS) Pakistan
  • Naveed Anjum 78 Medical Battalion Okara /National University of Medical Sciences (NUMS) Pakistan
  • Saeed Bin Ayaz Combined Military Hospital Jhelum/National University of Medical Sciences (NUMS) Pakistan
  • Kanza Khalid FC Hospital Quetta Pakistan
  • Muhammad Saleem 142 Medical Battalion Gujranwala /National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Javad Yousaf Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: Association, Coronary artery disease, Diabetes mellitus, Gensini score, Hyperuricemia, Hypertension

Abstract

Objective: To determine frequency of elevated serum uric acid levels in patients with coronary artery disease, association of hyperuricemia with severity of coronary artery disease, gender, age, hypertension, and diabetes mellitus.

Study Design: Cross-sectional study.

Place and Duration of Study: Internal Medicine department, Combined Military Hospital Multan, from Nov 2015 to May 2016.

Methodology: One hundred and fifty patients with coronary artery disease were selected consecutively and admitted for coronary angiography. Serum uric acid levels were evaluated after eight hours fasting by photometric technique having normal reference range of 3.5-6.7 mg/dL. Coronary angiography was performed and Gensini score computed. To compare mean Gensini score between normouricemic and hyperuricemic population, student’s t-test was applied.

Results: A total of 150 study cases (mean age: 54.4 ± 8.5 years), 101 (67.3%) were male while 49 (32.7%) were female. Diabetes mellitus was present in 43 (28.7%) of cases and hypertension was present in 65 (43.3%). Hyperuricemia was noted in 58 (38.7%) of cases. The mean Gensini score in hyperuricemic patients was significantly higher (40.31 ± 14.64) compared to patients with normal serum uric acid levels (25.02 ± 10.94) (p<0.001). The frequency of hyperuricemia was significantly higher in males, patients ≤60 years of age, and patients with diabetes mellitus (p<0.001, p=0.001 and p=0.001). No significant asso-ciation with hypertension was observed (p=0.314).

Conclusion: Frequency of 38.7% for hyperuricemia was noted in our study among patients with coronary artery disease. Hyperuricemia was significantly associated with higher Gensini score, male gender, younger age, and diabetes mellitus.

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Published
2021-04-30
How to Cite
Raza, S., Anjum, N., Ayaz, S., Khalid, K., Saleem, M., & Yousaf, M. (2021). FREQUENCY OF HYPERURICEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE AND ITS ASSOCIATION WITH DISEASE SEVERITY, AGE, GENDER, DIABETES MELLITUS, AND HYPERTENSION. PAFMJ, 71(2), 651-54. Retrieved from https://mail.pafmj.org/index.php/PAFMJ/article/view/6676
Section
Original Articles

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