Pattern of Different Immunohistochemical Stains in Various Types of Hepatoblastoma

  • Hina Maqbool Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Sajid Mushtaq Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Mudassar Hussain Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Umer Nisar Sheikh Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Usman Hassan Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Saud Sarwar Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Maryam Hameed Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Mohammad Tariq Mehmood Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
  • Asad Hayat Ahmad Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar Pakistan
Keywords: Hepatoblastoma, Immunohistochemical stains, Liver neoplasm

Abstract

Objective: To assess the utility of four immunohistochemical stains in the categorization of hepatoblastoma.

Study Design: Retrospective longitudinal study.

Place and Duration of Study: Histopathology Department, Shaukat Khanum Memorial Cancer Hospital, Peshawar Pakistan, from 2016 to 2018.

Methodology: We retrospectively reviewed 50 cases of hepatoblastoma from 2016-2018, from our hospital database and studied the pattern of four immunohistochemical stains (Beta-catenin, Glutamine synthetase, Heppar 1 and Cyclin D1) in various subtypes.

Results: Ten out of fifty cases were mixed epithelial and mesenchymal hepatoblastomas, and forty were pure epithelial. In the pure epithelial category, the fetal subtype showed Heppar 1 and Cyclin D1 positivity in twenty-eight cases, while Glutamine synthetase and Beta-catenin were positive in all the thirty cases. One case of embryonal subtype displayed negativity for Heppar 1; the rest of the immunohistochemical stains were positive. Ten tumours exhibiting mixed epithelial and mesenchymal morphology showed positivity for all the four immunohistochemical stains in the epithelial component. However, Heppar 1 and cyclin D1 were negative in the mesenchymal component in all the ten cases. Five cases (50%) showed Glutamine synthetase and Beta-catenin positivity in the mesenchymal component.

Conclusion: All the four immunohistochemical stains, especially Beta-catenin and Glutamine synthetase, were efficient diagnostic tool, especially for tumours with complex or vague morphological features.

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Published
2022-04-28
How to Cite
Maqbool, H., Mushtaq, S., Hussain, M., Sheikh, U., Hassan, U., Sarwar, S., Hameed, M., Mehmood, M., & Ahmad, A. (2022). Pattern of Different Immunohistochemical Stains in Various Types of Hepatoblastoma. Pakistan Armed Forces Medical Journal (PAFMJ), 72(2), 363-66. https://doi.org/10.51253/pafmj.v72i2.5182
Section
Original Articles