FREQUENCY OF PAIN DUE TO INJECTION OF PROPOFOL WITH IV ADMINISTRATION OF LIGNOCAINE WITH AND WITHOUT METOCLOPRAMIDE
Keywords:Lidocaine, Metoclopramide, Pain on Propofol
Objective: To determine the frequency of Propofol associated pain in patients undergoing general anaesthesia using lignocaine alone and metoclopramide given prior to lignocaine.
Study Design: Double blind Randomized controlled trial.
Place and Duration of Study: It was conducted in Anaesthesia department, Combined Military Hospital, Rawalpindi; over a period of Six Months from 20-02-2011 to 19-08-2011
Material and Methods: One hundred and twenty Patients were included in the study, and were randomly divided into two groups of 60 each. 20 ml (1% aqueous) Propofol solution was mixed with 2 ml of 2% lignocaine. Propofol dose was calculated as 2 mg/kg. Group A were given intravenous 10mg metoclopramide. One fourth dose of propofol (1% aqueous solution) was then given in the most prominent vein of the hand through cannula at a rate of 1 mL/s. Group B were given intravenous normal saline instead of metoclopramide, and then received 25% the total dose of propofol mixed with lignocaine in the same manner.
Results: Mean age was 31 ± 5.07 and 32.9 ± 6.42 in group- A and B respectively. In group-A, 70%patients and in group-B, 65%patients were male. Pain was present in 4(6.7%) patients in group-A, and in 13 (21.7%) patients in group-B. Significant difference between two groups was found (p=0.018).
Conclusion: It is concluded from this study, that intravenous metoclopramide given prior to mixture of lidocaine and propofol is superior to administration of lidocaine mixed with propofol alone to prevent propofol induced pain.