Perinatal Stroke; Risk Factors and Outcome. A Study from Aga Khan University Hospital Karachi

  • Fozia Baloch Aga Khan University Hospitals, Karachi Pakistan
  • Falak Abro Aga Khan University Hospitals, Karachi Pakistan
  • Qurat-Ul-Ain Khalid Aga Khan University Hospitals, Karachi Pakistan
  • Prem Chand Aga Khan University Hospitals, Karachi Pakistan
Keywords: Neonatal ischemic stroke, Neonatal stroke, Perinatal hemorrhagic stroke, Perinatal stroke

Abstract

Objective: To determine the frequency, risk factors and the outcomes of a perinatal stroke.

Study Design: Cross-sectional study.

Place and Duration of Study: Neonatal Intensive Care Unit, Department of Pediatrics, Aga Khan University Hospital, Karachi Pakistan, from Jan to Dec 2019.

Methodology: Neonates with perinatal stroke confirmed on the neuroimaging, were included in the study. The primary outcomes were risk factors, divided into 3 groups, maternal, placental and neonatal. The secondary outcome was the condition at the time of the discharge.

Results: A total of 58 patients were included in the study. Maternal risk factors identified in the study, were intrauterine infections 10 (17.2%), anti-phospholipid syndrome, gestational diabetes 8 (13.8%) and preeclampsia 7 (12.1%). Chorioamnionitis 9 (15.5%), antepartum hemorrhage 6 (10.3%), and placenta previa 4 (6.9%) were the placental risk factors. Neonatal risk factors were birth asphyxia 35 (60.3%), sepsis/meningitis 8 (13.8%), premature birth 6 (10.3%) and fetal bradycardia 4 (6.9%). Resuscitation was needed in 35 (60.3%) neonates with birth asphyxia. Haemorrhagic stroke was observed in 38 (65.5%) cases, ischemic stroke in 14 (24.1%) cases and mixed type of stroke was found in 6 (10.3%) patients. The total mortality rate in our study was
13.8%.

Conclusion: Haemorrhagic stroke was more common than ischemic or mixed stroke among the patients of perinatal stroke at our healthcare facility. Patients with low APGAR score at 5 minutes, birth asphyxia and male gender, were most affected.

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Published
2022-03-01
How to Cite
Baloch, F., Abro, F., Khalid, Q.-U.-A., & Chand, P. (2022). Perinatal Stroke; Risk Factors and Outcome. A Study from Aga Khan University Hospital Karachi. Pakistan Armed Forces Medical Journal (PAFMJ), 72(1), 215-19. https://doi.org/10.51253/pafmj.v72i1.4863
Section
Original Articles