EVALUATION OF IMPROVEMENT IN RENAL FUNCTION AFTER FIRST-LINE CHEMOTHERAPY IN MULTIPLE MYELOMA PATIENTS PRESENTING WITH RENAL IMPAIRMENT

  • Syed Abdul Mannan Hamdani Shaukat Khanum Memorial Cancer Hospital, Lahore Pakistan
  • Abdul Wahab Shaukat Khanum Memorial Cancer Hospital, Lahore Pakistan
  • Musa Azhar Shaukat Khanum Memorial Cancer Hospital, Lahore Pakistan
  • Faiza Iftikhar Shaukat Khanum Memorial Cancer Hospital, Lahore Pakistan
  • Bushra Ahsan Shaukat Khanum Memorial Cancer Hospital, Lahore Pakistan
  • Usman Ahmad Shaukat Khanum Memorial Cancer Hospital, Lahore Pakistan
Keywords: Boretzomib and dexamethasone, Boretezomib, Cyclophosphamde, Cyclophosphamide and dexamethasone, Estimated glomerular filtration rate, Lenalidomide, Multiple myeloma, Renal impairment, Thalidomide and dexamethasone

Abstract

Objective: To evaluate the effect of response to first-line chemotherapy on renal functions in multiple myeloma (MM) patients.

Study Design: Cross-sectional study.

Place and Duration of Study: Shaukat Khanum Memorial Cancer Hospital, Lahore, from Jan 2013 to Dec 2017.

Methodology: Multiple myeloma patients with renal impairment (RI) at baseline were included. Data was collected from the hospital registry.The variables assessed pre and post first-line chemotherapywere age, gender, initial estimated glomerular filteration rate and serum creatinine levels. Progression-free survivaland overall survival (OS) was calculated for both groups of patients i.e those who had improvement in renal funtions and those who did not show improvement. Kaplan-Meier curves were drawn, and SPSS-20 was used for data analysis.

Results: Mean age was 48 ± 7 years. Out of 139 myeloma patients, 35 (25.1%) had RI at baseline. Males were 23 (65.7%), while females were 12 (34.3%). Cyclophosphamide, thalidomide and deamethsone (CTD)were used in the majority 30 (85.7%) followed by boretzomib, thalidomide and dexamethasone (VTD) in 2 (5.7%) patients. Boretezomib and dexamethasone (BorDex), lenalidomide and dexamethasone (Len Dex), lenalidomde, cyclophosphamide and dexamethasone (LCD) were given to 1 (2.8%) patient each. Serum creatinine levels normalized in 19 (54.3%). Dialysis was required in 11 (31.4%) patients out of which 3 (8.6%) got dialysis-independent while 8 (22.9%) patients remained dialysis-dependent. The medianoverall survival in whom
creatinine levels normalized was 35 months while it was 15 months in those in whom it did not normalize.

Conclusion: Prompt administration of chemotherapy regimens can lead to an improvement in renal function....................

Downloads

Download data is not yet available.
Published
2021-08-27
How to Cite
Hamdani, S. A. M., Wahab, A., Azhar, M., Iftikhar, F., Ahsan, B., & Ahmad, U. (2021). EVALUATION OF IMPROVEMENT IN RENAL FUNCTION AFTER FIRST-LINE CHEMOTHERAPY IN MULTIPLE MYELOMA PATIENTS PRESENTING WITH RENAL IMPAIRMENT. PAFMJ, 71(4), 1431-35. https://doi.org/10.51253/pafmj.v71i4.4850
Section
Original Articles