Prevalence of Blood Group A2 in Northern Pakistan

  • Muhammad Sajid Yazdani Combined Military Hospital Abbottabad/National University of Medical Sciences (NUMS) Pakistan
  • Zeeshan Khalid Armed Forces Post Graduate Medical Institute/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Ali Rathore Armed Forces Institute of Transfusion/National University of Medical Sciences (NUMS) Rawalpindi Pakistan,
  • Sarah Fatimah Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: A2 blood group, A2B blood group, Subgroups of A blood group


Objective: To determine the prevalence of A1 and A2 subgroups of blood group A in healthy blood donors of northern Pakistan.

Study Design: Cross sectional study.

Place and Duration of Study: Armed Forces Institute of Transfusion, Rawalpindi Pakistan, from Sep to Dec 2017.

Methodology: The blood samples of donors reported during the study period at Armed Forces Institute of Transfusion were collected. ABO typing was performed and those in group A and AB were further subtyped using anti-A1 lectin and thus the individuals were labelled as A1 (and A1B) or A2 (and A2B). The serum of individuals with groups A2 and A2B was tested for anti-A1 based on the reaction with A1 red cells.

Results: Out of total 4485 donors, 1116 (24.88%) were of blood group A and 422 (9.41%) individuals were of AB group. Out of 146 (13.08%) individuals among 1116 blood group A donors were of subgroup A2. While out of 422 of blood group AB, 80 (18.95%) were A2B. 21 (14.38%) out of 146 individuals of A2 blood group, had anti-A1 antibody while among 80 individuals with A2B blood group only 2 (2.50%) had anti-A1 antibody in their serum.

Conclusion: Blood group A2 is quite prevalent in our population. Although anti-A1 is present in significant fraction of A2 blood group individuals, the routine testing is not needed to identify the A2 group and cross match compatibility is the only requirement as anti-A1 is rarely active at 37° C.


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How to Cite
Yazdani, M., Khalid, Z., Rathore, M., & Fatimah, S. (2022). Prevalence of Blood Group A2 in Northern Pakistan. Pakistan Armed Forces Medical Journal, 72(1), 47-50.
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