N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDES IN INFANTS AND CHILDREN WITH NON-CARDIAC DISEASES

  • Humaira Ali Liaquat National Hospital, Karachi Pakistan
  • Junaid M Alam, Dr Liaquat National Hospital, Karachi Pakistan
  • Shazia Naureen Liaquat National Hospital, Karachi Pakistan
Keywords: N- terminal pro-b-type natriuretic peptide, Non-cardiac diseases, Pediatric patients

Abstract

Objective: To evaluate the levels of N-terminal pro-B-type Natriuretic Peptide in infants and children with non-cardiac diseases especially respiratory diseases.

Study Design: Cross-sectional study.

Place and Duration of Study: Department of Chemical Pathology/Biochemistry Laboratory Services of Liaquat National Hospital Karachi Pakistan, from Dec 2018 to Nov 2019.

Methodology: Infants and children admitted to the Pediatric department with non-cardiac diseases were included in the study. Non-probability consecutive sampling was done. Blood was taken and analyzed for N- terminal pro-B-type Natriuretic Peptide, Troponin I, urea, creatinine, Lactate dehydrogenase, Creatinine Kinase, lactate and sodium analysis.

Results: Out of the 93 patients, 74 (80%) were diagnosed with respiratory disorders, with bronchopneumonia making up 54 (59%) Bronchiolitis 15 (17%) and 4% had miscellaneous respiratory diseases. Out of the remaining 20%, 8 (9%) patients were diagnosed with sepsis, and the remaining 11% were diagnosed with miscellaneous diseases. There was a positive correlation of N- terminal pro-B-type Natriuretic Peptide with Troponin I, urea, creatinine, Creatinine Kinase and Lactate dehydrogenase levels (p<0.05).

Conclusion: N- terminal pro-B-type Natriuretic Peptide levels were found to be raised in pediatric patients with non-cardiac diseases especially broncho-pneumonia and in future it may be used as a marker of bronchopneumonia in children.

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Published
2021-06-29
How to Cite
Ali, H., Alam, J., & Naureen, S. (2021). N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDES IN INFANTS AND CHILDREN WITH NON-CARDIAC DISEASES. PAFMJ, 71(3), 840-43. https://doi.org/10.51253/pafmj.v71i3.3781
Section
Original Articles