Frequency and Culture Sensitivity for Bacteremia During Febrile Neutropenia in Children with Acute Lymphoblastic Leukemia. Do Age and Gender Matter?

  • Rana Usama Bin Mehmood Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
  • Afra Aslam Shifa International Hospital, Islamabad Pakistan
  • Saeed Bin Ayaz Combined Military Hospital Jhelum/National University of Medical Sciences (NUMS) Pakistan
  • Shehla Choudhry Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
  • Sidra Javed Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
  • Khaula Ashraf Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Keywords: Antibiotic susceptibility, Bacteremia, Blood cultures, Children, Febrile neutropenia

Abstract

Objectives: To determine the frequency of bacteremia and its association with age and gender in febrile neutropenic children suffering from acute lymphoblastic leukemia and identify the commonest pathogens and their antibiotic susceptibility identified on blood cultures.

Study Design: Cross-sectional analytical study

Place and Duration of Study: Pediatrics Inpatient Department, Shifa International Hospital, Islamabad Pakistan, from Sep 2018 to Mar 2019.

Methodology: Children with acute lymphoblastic leukemia aged 1-12 years, presenting with temperature >100ºF and absolute neutrophil count of <500 cells/µL were enrolled. An automated blood culture system was used and Clinical and Laboratory Standards Institute Guidelines 2017 were used for susceptibility testing. Antibiotics were started empirically in all cases and changed after susceptibility testing.

Results: A total of 62 children were enrolled. The mean age was 8.6 ± 2.4 years. Majority of the children i.e., 32 (51.6%) were females. The frequency of bacteremia was 16 (25.8%) and there was no significant association with age or gender (p=0.475 and p=0.881 respectively). Majority of the isolates were gram-positive. The organism isolated in the highest frequency was Methicillin-Resistant Staphylococcus Epidermidis (MRSE) 5 (31.25%). Susceptibility to Vancomycin was present in 10 isolates while seven isolates were sensitive to penicillins/cephalosporins.

Conclusion: Bacteremia, primarily caused by gram-positive bacteria was found in 25.8% of our sample and was uninfluenced by age or gender. MRSE was the most frequent isolate. The bacterial isolates were susceptible primarily to vancomycin and penicillins/cephalosporins.

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Published
2022-06-02
How to Cite
Bin Mehmood, R., Aslam, A., Ayaz, S., Choudhry, S., Javed, S., & Ashraf, K. (2022). Frequency and Culture Sensitivity for Bacteremia During Febrile Neutropenia in Children with Acute Lymphoblastic Leukemia. Do Age and Gender Matter?. Pakistan Armed Forces Medical Journal, 72(SUPPL-2), S229-34. https://doi.org/10.51253/pafmj.v72iSUPPL-2.3609
Section
Original Articles