FREQUENCY AND CORRELATES OF MYOPATHY IN PATIENTS WITH DIABETES TAKING ATORVASTATIN

  • Kamil Rehman Butt Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Andaleeb Khan Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Ali Muhammad Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Jawad Khan Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Ejaz Ali Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Usama Bin Zubair Pakistan Institute of Medical Sciences, Islamabad Pakistan
Keywords: Atorvastatin, Diabetes mellitus, Myopathy

Abstract

Objective: To determine the myopathy in patients with diabetes taking atorvastatin and look for the factors correlated with the presence of myopathy among these patients.

Study Design: Cross sectional analytical study.

Place and Duration of Study: Department of Medicine, Pak Emirates Military Hospital Rawalpindi from, Jul to Dec 2018.

Methodology: A total of 166 patients of both genders with type 2 diabetes mellitus taking atorvastatin for at least three to twelve months were included. Blood samples were drawn and Creatinine kinase (CK) levels were determined by automated analysis by colorimetry. Myopathy was taken as muscle symptoms associated with elevations in Creatinine Kinase at least 10 times the upper limit of normal.

Results: Mean age of patients was 51.530 ± 5.70 years with age range from 40-70 years with. Mean duration of diabetes was 6.174 ± 2.27 years, mean duration of taking atorvastatin 7.186 ± 2.17 months and mean creatinine kinase levels were 1760.325 ± 5111.71 IU/L. Males were 68.7% as compare to females 31.3%. Myopathy was seen in 8.4% patients. Long duration of Diabetes Mellitus and atorvastatin use was statistically significantly related with the presence of myopathy.

Conclusion: Myopathy was found in a significant number of patients taking atorvastatin. High risk population in our study emerged out to be patients with long duration of Diabetes Mellitus and long use of atorvastatin.

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Author Biography

Jawad Khan, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

Dr Jawad Khan

FCPS  (pulmonology) ,Resident Critical Care Medicine, PEMH Rawalpindi.

Phone no. 0346-9060064

Published
2021-04-28
How to Cite
Butt, K., Khan, A., Muhammad, A., Khan, J., Ali, E., & Zubair, U. (2021). FREQUENCY AND CORRELATES OF MYOPATHY IN PATIENTS WITH DIABETES TAKING ATORVASTATIN. PAFMJ, 71(2), 482-85. https://doi.org/10.51253/pafmj.v71i2.2924
Section
Original Articles

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