THE COMPLETE CLINICAL RESPONSE IN RECTAL CARCINOMA AFTER CHEMO RADIATION

Rectal Carcinoma After Chemo Radiation

  • Ammara Manzoor Jinnah Postgraduate Medical Centre Karachi Pakistan
  • Ghulam Haider Jinnah Postgraduate Medical Centre Karachi Pakistan
  • Saima Zahoor Jinnah Postgraduate Medical Centre Karachi Pakistan
  • Ravisha Bai Jinnah Postgraduate Medical Centre Karachi Pakistan
  • Muhammad Ejaz Khan Jinnah Postgraduate Medical Centre Karachi Pakistan
  • Maqbool Ahmad Jinnah Postgraduate Medical Centre Karachi Pakistan
Keywords: Advanced adenocarcinoma rectal cancer, Chemo-radiation, Complete clinical response (cCR), Neoadjuvant, chemoradiotherapy, Pelvic CT/MRI

Abstract

Objective: To determine the complete clinical response in rectal carcinoma after neoadjuvant chemo radiation.
Study Design: Cross-sectional study.
Place and Duration of Study: This study was conducted in Clinical Oncology department, Jinnah Postgraduate
Medical Centre Karachi, from Jan 2016 to Jan 2017.
Material and Methods: Seventy Two Patients meeting the inclusion criteria were enrolled in study after complete
staging workup. Neoadjuvant concurrent chemoradiotherapy was planned, consisting of oral capecitabine
825mg/m2 BID five days a week along with 50.4 Gy Radiotherapy with linac machine. Radiation was delivered
over a period of 5 weeks at a rate of 1.8 Gy/day. Patients received Radiotherapy in Atomic Energy Medical
Centre (AEMC) and in Sindh Institute Urology & Transplant (SIUT), Radiation department. Chemotherapy was
given in clinical oncology department of JPMC. Sixty one patients completed planned treatment and were
available for post concomitant chemo radiotherapy response assessment with Pelvic CT/MRI after 6-8 weeks of
completion of concomitant chemo radiotherapy. Response assessment was done according to Response Evaluation
Criteria in solid tumor (RECIST) criteria version 1.1 and then Patients were referred for surgical evaluation.
Result: A total of 61 cases of locally advanced adenocarcinoma rectal cancer patients were included in the study.
Mean age of the patients was 41 years with ± 17.06 years SD. Complete clinical response was identified in 4 (6.6%)
while 31 (50.8%) were identified as partial response, progressive disease was 13 (21.3%) and 13 (21.3%) were with
stable disease. All confounding variables were found statistically significant with p-value found less than 0.05.
Conclusion: Neo-adjuvant chemoradiotherapy for locally advanced rectal cancer is associated with high rates of
tumor response in terms of downs tagging (complete & partial) and is relatively safe with acceptable morbidity,
which favors its use in future.

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Published
2018-10-31
How to Cite
Manzoor, A., Haider, G., Zahoor, S., Bai, R., Khan, M. E., & Ahmad, M. (2018). THE COMPLETE CLINICAL RESPONSE IN RECTAL CARCINOMA AFTER CHEMO RADIATION. Pakistan Armed Forces Medical Journal, 68(5), 1179-85. Retrieved from https://mail.pafmj.org/index.php/PAFMJ/article/view/2287
Section
Original Articles