ANALYSIS OF ESTROGEN RECEPTOR (ER) AND PROGESTRONE RECEPTOR (PR) EXPRESSION IN SURFACE EPITHELIAL TUMORS OF OVARY AND ITS CORRELATION WITH THEIR CLINICAL STAGE

ER and PR Expression in Tumors of Ovary

  • Madeeha Anwar Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Asif Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Riaz Ahmed Combined Military Hospital/ National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Tahir Khadim Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Hamza Mansur Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan,
  • Rabia Ahmed Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: Clinical stage, Estrogen receptor, Immunohistochemistry, Ovarian cancer, Progesterone receptor

Abstract

Objective: To evaluate ER and PR expression in epithelial ovarian cancers (EOC) and to determine its association
with clinical stage.
Study Design: Cross sectional study.
Place and Duration of Study: Histopathology department, Armed Forces Institute of Pathology (AFIP)
Rawalpindi, from Mar to Oct 2017.
Material and Methods: A total of thirty three (n=33) histologically confirmed EOCs were analyzed. ER and PR
expression status was assessed by immunohistochemistry using Allred scoring system and was compared with
the clinical stage defined by The International Federation of Gynecology and Obstetrics (FIGO) staging system.
Results: A total of thirty three (n=33) females were enrolled. Mean age of the study females was 50.8 ± 12.9 years.
Most frequent histologic type was serous carcinoma (SC) 60.6% (n=20) followed by mucinous carcinoma (MC)
15.2% (n=5), endometrioid carcinoma (EC) 9.1% (n=3), clear cell carcinoma (CC) 9.1% (n=3), Brenner tumor (MBT)
3% (n=1) and seromucinous carcinoma (SMC) 3% (n=1). Most patients were in clinical stage I 61% (n=20)
followed by stage II 24%, (n=8) and stage III 15% (n=5). Among SC, 90.0% (n=18/20) were ER and 65% (n=13/20)
were PR-positive. All MC and CC were ER/PR negative. Two of the three ECs were ER and one was PR-positive.
Higher percentage of stage I tumors exhibited ER 65% (n=13/20) and PR 45% (n=9/20) positive status (p>0.5).
The correlation was very weak positive between clinical stages and both ER and PR scores (Allred) r=0.11 and
0.15 respectively p>0.05.
Conclusion: Higher percentages of stage I tumors exhibited ER and PR positive status yet not statistically
significant from stage II/III. Estimation of ER and PR receptor status may help to select the women with ovarian
malignancy for hormonal therapy, which is more likely to improve the response rate.

Downloads

Download data is not yet available.
Published
2018-10-31
How to Cite
Anwar, M., Asif, M., Ahmed, R., Khadim, M. T., Mansur, H., & Ahmed, R. (2018). ANALYSIS OF ESTROGEN RECEPTOR (ER) AND PROGESTRONE RECEPTOR (PR) EXPRESSION IN SURFACE EPITHELIAL TUMORS OF OVARY AND ITS CORRELATION WITH THEIR CLINICAL STAGE. Pakistan Armed Forces Medical Journal, 68(5), 1121-25. Retrieved from https://mail.pafmj.org/index.php/PAFMJ/article/view/2276
Section
Original Articles

Most read articles by the same author(s)

1 2 > >>