SURVIVIN AND CK2 CO-EXPRESSION IN HUMAN PROSTATE CANCER
Survivin and Ck2 Co-Expression in Prostate Cancer
Objective: To check the co-expression of survivin and CK2 in prostate cancer patients as compared to the Benign Prostatic Hyperplasia (BPH) patients.
Study Design: Cross-sectional analytical study.
Place and Duration of Study: This study was conducted at Armed Forces Institute of Pathology, Army Medical College Rawalpindi, from Dec 2012 to April 2014.
Material and Methods: The study was designed as a cross-sectional analytical study and conducted at Armed Forces Institute of Pathology, Army Medical College Rawalpindi, from Dec 2012 to April 2014, after approval from institutional ethical committee. Expression of survivin was analyzed by immunostaining in paraffinembedded sections from 30 diagnosed cases of resected prostate cancer and 30 BPH cases that were also immune stained for CK2.
Results: The CK2 and survivin were found to overexpress in prostate cancer as compared to BPH. Total score of CK2 survivin were strongly positive and significantly correlated in non-invasive cases as compared to BPH.
Conclusion: There is a strong positive correlation between survivin and CK2 over-expression in prostate cancerpatients specifically non-invasive cases suggesting the coordination between the two proteins in early stages ofprostate cancer progression.