COMPARISON OF SERUM LIPID PROFILE IN NON ALCOHOLIC FATTY LIVER DISEASE

  • Atif Latif, Pakistan Naval Ship (PNS) Shifa Hospital, Karachi Pakistan
  • Qurrat- Ul-Ain Pakistan Naval Ship (PNS) Shifa Hospital, Karachi Pakistan
  • Syed Raza Jafer Pakistan Naval Ship (PNS) Shifa Hospital, Karachi Pakistan
  • Nisar Ahmed Pakistan Naval Ship (PNS) Shifa Hospital, Karachi Pakistan
  • Mazhar Shafiq Pakistan Naval Ship (PNS) Shifa Hospital, Karachi Pakistan
  • Kumari Sapna Pakistan Naval Ship (PNS) Shifa Hospital, Karachi Pakistan
Keywords: Lipid profile, Non-alcoholic fatty liver disease (NAFLD),, NonHDL cholesterol, Ultrasonography.

Abstract

Objective: To compare serum lipid profile in different ultrasonographic grades of non alcoholic fatty liver disease (NAFLD).
Study Design: Cross sectional study.
Place and Duration of Study: PNS SHIFA hospital, Karachi, from Oct 2015 to Jul 2016.
Material and Methods: Seventy three adults of either gender were consecutively inducted after diagnosis of non alcoholic fatty liver disease (NAFLD) on ultrasonography (USG). These individuals were further classified into grade I, II and III of NAFLD depending on US findings. Fasting blood sample of all the subjects was analyzed for serum fasting lipid profile comprising of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Serum non HDL cholesterol (nonHDL-C)
was calculated by subtracting HDL-C from TC.
Results: Among 73 subjects with NAFLD, 42.5%, 37% and 20.5% had grade I, II and III NAFLD respectively. All parameters showed significant increase in frequency of abnormal results with increasing grade of NAFLD except TG. Significant difference was found in mean TC (p=0.000), LDL-C (p=0.000), HDL-C (p=0.005) and nonHDL-C (p=0.000) between grades of NAFLD. Post hoc analysis revealed that only mean nonHDL-C was significantly different amongst all the grades of NAFLD.
Conclusion: The increasing severity of NAFLD was found associated with increased frequency of dyslipidemia. Though most frequent dyslipidemia in NAFLD was low serum HDL-C followed by hypertriglyceridemia, only serum nonHDL-C was statistically different amongst all the grades of NAFLD.

 

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Published
2017-10-30
How to Cite
Latif, A., Ul-Ain, Q.-, Raza Jafer, S., Ahmed, N., Shafiq, M., & Sapna, K. (2017). COMPARISON OF SERUM LIPID PROFILE IN NON ALCOHOLIC FATTY LIVER DISEASE. Pakistan Armed Forces Medical Journal, 67(6), 930-35. Retrieved from https://mail.pafmj.org/index.php/PAFMJ/article/view/1105
Section
Original Articles