DRUG INDUCED ACUTE KIDNEY INJURY: AN EXPERIMENTAL ANIMAL STUDY

Drug Induced Acute Kidney Injury

  • Muhammad Waqar Aslam Khan
  • Rizwan Aziz Qazi Pakistan Institute of Medical Sciences Islamabad Pakistan,
  • Muhammad Ashraf NESCOM Hospital Islamabad Pakistan
  • Naila Bashir *Pakistan Institute of Medical Sciences Islamabad Pakistan
  • Maryam Waqar Armed Forces Institute of Dentistry (AFID)/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Bushra Tayyaba Khan Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: Iatrogenic,, Interstitial cells, Morbidity

Abstract

Objective: To assess the extent of drug induced nephrotoxicity in laboratory animals for determining the role and extent of iatrogenic kidney damage in patients exposed to nephrotoxic drugs in various clinical setups.
Study Design: Randomized control trail.
Place and Duration of study: Pharmacology department and animal house of Army Medical College from Jan  2011 to Aug 2011.
Material and Methods: Thirty six mixed breed rabbits were used in this study. Animals were randomly divided into six groups consisting of six rabbits in each. Groups were named A, B, C, D, E and F. Group A was control group. Group B was given 0.9% normal saline. Group C rabbits were given acute nephrotoxic single dose of amphotericin B deoxycholate. Group D received 0.9% normal saline 10ml/kg followed by amphotericin B infusion. Group E was injected acute nephrotoxic regimen of cyclosporine and amphotericin B infusion. Group F received saline loading along with acute nephrotoxic regimen of cyclosporine and amphotericin B infusion.
Results: Biochemical and histopathological analysis showed significant kidney injury in rabbits exposed to acute nephrotoxic doses of amphotericin B and cyclosporine. Toxicity was additive when the two drugs were administered simultaneously. Group of rabbits with saline loading had significantly lesser kidney damage.
Conclusion: Iatrogenic acute kidney damage is a major cause of morbidity in experimental animals exposed to such nephrotoxic drugs like amphotericin B and cyclosporine, used either alone or in combination. Clinical studies are recommended to assess the extent of iatrogenic renal damage in patients and its economic burden. Efficient and cost effective protective measure may be adopted in clinical setups against such adverse effects.

 

Downloads

Download data is not yet available.
Published
2017-10-30
How to Cite
Aslam Khan, M. W., Aziz Qazi, R., Ashraf, M., Bashir, N., Waqar, M., & Tayyaba Khan, B. (2017). DRUG INDUCED ACUTE KIDNEY INJURY: AN EXPERIMENTAL ANIMAL STUDY. Pakistan Armed Forces Medical Journal, 67(6), 899-903. Retrieved from https://mail.pafmj.org/index.php/PAFMJ/article/view/1035
Section
Original Articles